Szczepionka na Sars-Cov (1) nie powstała, bo wszystkie zwierzęta laboratoryjne zaszczepione próbnie testowanymi preparatami, po kontakcie z wirusem wytwarzały nadwrażliwość na Sars-Cov
Wszystkie testowane szczepionki na Sars-Cov generowały przeciwciała, ale kontakt z patogenem powodował zaburzenia produkcji cytokin TH2. (Th2-type immunopathology). Zrezygnowano z testów na ludziach.
Huston, mamy problem.
Aby sprawdzić czy problem z nadwrażliwością typu II zaobserwowany u zwierząt poddanych szczepieniu szepionkami na Sars-Cov (1) pojawia się u ludzi zaszczepionych na Sars-Cov-2, z którego to powodu zrezygnowano z dalszych badań nad tamtymi szczepionkami, konieczne jest przeprowadzenie pod tym kątem autopsji. Dlaczego ich się nie robi?
The NIH definition of Type 2 hypersensitivity.
Type II hypersensitivity reaction refers to an antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens, resulting in cellular destruction, functional loss, or tissue damage.
Link to further information on Type II hypersensitivity >
Type 2 hypersensitivity responses are my major concern. In this situation, antibodies produced against the virus target proteins on the surface of cells leading to inflammation.
As shown, all animals exhibited pathologic changes after challenge including those animals with no measurable virus on day two suggesting virus infection had occurred but was not detectable on day two because of a short duration of infection or neutralization of virus by antibody in the lung during processing.
- Tseng, Chien-Te, et al. "Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus." PloS one 7.4 (2012): e35421.
If Type II hypersensitivity responses are also occurring today with current vaccines, the only way of knowing this is through detailed autopsies on vaccinated deaths. Currently, minimal such autopsies have been done (I could find only 29 published up till spring 2022) after 12 billion vaccine doses delivered.
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- Tseng, Chien-Te, et al. "Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus." PloS one 7.4 (2012): e35421.
Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this. The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the Th1 mediated microbicidal action. The optimal scenario would therefore seem to be that humans should produce a well balanced Th1 and Th2 response, suited to the immune challenge. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27457/