"Jest już 5 po 12" - ostatnie przesłanie Geert Vanden Bossche
Co się będzie działo w wysoce wyszczepionych kpo wprowadzeniu aktualizowanych szczepionek na Covid?. Ostatnie ostrzeżenie od wirusologa, którego wcześniejsze przwidywania sprawdzały się dotąd w 100%.
(całość tekstu w 2 częściach)
It is 5 past 12 !
Hello everyone. My name is Geert Vanden Bossche. I'm a seasoned vaccinologist with background in veterinary medicine, in biology, immunology, microbial diseases. I have been sending out video messages before and this is probably the last one I'm going to do. I will still write articles, I will still do interviews.
But this is my last video message. And the reason why I'm sending out this video message is because I can no longer stand it. For me, it has become unbearable to see how our health authorities, our experts and governments are still trying to make people believe that the COVID-19 vaccines are safe and that they will be able to control the pandemic. In this presentation I made a few PowerPoint slides. I will show you that, as I have already been saying in the past, this is an unbelievable blunder. It is an insult to the science. It is unbelievable how scientists can still support this kind of strategy, whereas there is overwhelming evidence that the mass vaccination and the upcoming or updated omicron vaccination will just make things much, much worse. So, this news is sobering, but I have no choice. I have to share it because we have a passion for the truth and we believe that the truth will prevail.
But let me share my screen to show you some slides that I have been presenting to, again, trying to make my case or trying to make the case.
So what I'm saying in this first slide is that it is five past twelve. In fact, we are already too late to intervene in a way that could prevent humanitarian crisis. It is really my last and desperate call for action as Omicron is now causing a fast and large-scale immune escape in vaccines. So, this is simply accelerating. Immune escape is accelerating.
It is really escalating and for me it is really unbelievable. I cannot understand how it is possible that all these researchers that are studying these mutations and this mutational escape of the virus are not ringing the alarm bell.
So I don't know, I really don't know. Is it stupidity or is it really willful blindness? The scientists who are analyzing all these new mutations that are simply accumulating, we have seen them accumulating even over the last days, over the last weeks. For the scientists, this doesn't seem to be a reason for panic really. I mean, they see this fulminant immune escape as in fact a great opportunity for making publications.
So I call them the variant spotters. Seems like they are enjoying this because this is now providing so much food for publications in peer review journals. And it is really about molecular stamp collection, identifying all these mutations, doing the deep mutational scanning, the neutralization assays, the ACE2 binding essays. All this to study the impact of amino acid substitutions, mutations, recombinations on the receptor binding affinity (this is a proxy for infectiousness) and to see how these changes can escape from the potentially neutralizing antibodies.
But we can do an analysis of course, on sera, sera from people who got vaccinated a single time, or triple vaccinated, who got boosted, who got first infected and then vaccinated, who got first vaccinated and then had breakthrough infections, you name it. And of course, they have whole series of monoclonals that they can test and see to what the extent the virus can resist these monoclonal neutralizing antibodies, or even the antibody drug cocktails. And I think if you do all this, given the fact that we are on the brink of a humanitarian crisis, and you do all things by matter of surveillance and just to document and just to try to understand what happened without any predictive value, I think this is a complete nonsense. It is a waste of time. When humanity is on the brink of humanitarian crisis, we need to gather information that is able to predict with a high level of fidelity, with a high level of confidence what is going to happen.
And they are not able to do this simply because they don't see the forest for the trees. And why is this? And here comes the thing. It is simply because they don't understand the underlying immune interaction between the virus and the immune system. They all agree that the convergent evolution of what they call themselves worrisome variants and the resulting immune escape, that all this is due to immune selection pressure that is placed on the virus.
But on the other hand, none of these researchers dares to mention that this huge immune selection pressure that they're finding out about, and that has become more and more obvious as the vaccine coverage rates were growing, that this could be due maybe to the mass vaccination, and that the changes to the mutational landscape are now only escalating. All this is very, very clear to them. But nobody dares to mention that this huge immune selection pressure has to do with the mass vaccination. I cannot believe this. And it's even worse:
On the contrary, these scientists who are excelling in what I call molecular stamp collection, these are the guys who are now also advocating for the development of broad-spectrum vaccines and antibody drugs. So continuation, please, with the vaccine program. And so, when I'm talking about the molecular stamp collection, I'm showing here a graph.
They like to do representations, cartographic representations, where you see, of course, all the different variants, the family tree, genealogy tree, and then also the kind of monoclonals that are resistant to the BA2, BA4, -5 derived descendants of those variants, et cetera, et cetera. And you can expand this like almost every week, we have additional variants that spread faster, that are more resistant to the neutralizing antibodies, you name it. So, the stamp collection is eternal. And to an extent that we see now in many publications how people are documenting this and with all the ramifications from the different predecessor strains or variants, and we have to document all the different mutations in the amino acids and where you then see how they are classified as different sublineages, subvariants, et cetera, et cetera. And as a matter of fact, some people are already making fun of this because, you know, they want to put names on all these variants. Initially we had the alpha, Gamma, delta, etc.
So why not continue? Why not continue this kind of Greek names or nicknames as some people have been doing. So, this is a kind of list of some of the most recent variants. And I've highlighted these two in yellow because they are right now (but tomorrow it could be just a different situation) the two strains, or variants I should say, that grow fast, grow faster than the others and that spread more rapidly and that are also the most resistant towards the neutralizing antibodies. So, it's a BQ.1.1 and the XBB. The latter is even a recombination of two already existing subvariants. So, it's a lot of fun doing the stamp collection, obviously. But as I was saying, what does it bring us in terms of predictive value and where is this circus going to end?
And here comes the key name, which is immune refocusing. You hear about imprinting and memory cells that get reactivated, etc. But I will tell you that none of these molecular epidemiologists or these variant watchers are really understanding the immunology that is now driving the fulminant expansion of these immune escape variants. So, I will try to explain you what is the driving force behind this. And I can already tell you it's called immune refocusing.
And immune refocusing, before I explain the mechanism, the effect of immune refocusing is that it expedites immune escape in vaccines. So, it accelerates it. And how does it do that? It does that by reorienting the immune response to antigens or part of antigens which we sometimes call epitopes, reorienting the immune response to antigens that basically recall previously vaccine primed antibodies that have lower neutralizing capacity.
So in fact, the new refocusing is redirecting the new response to antigens that have a poor potential of inducing neutralizing antibodies. So how does that work? Well, let me first tell you when this happens. When does this happen? This happens when an immune system is confronted with an antigen in the presence of preexisting antibodies against a similar antigen that is however not identical.
That is one possibility. And the nicest example of that one is of course when we get breakthrough infections ... because when we have breakthrough infections, very clearly the preexisting antibodies were unable to prevent the new variant (so the new antigen) from causing an infection or even causing disease. So very clearly the preexisting antibodies are not recognizing the new antigen. So the immune system is confronting an antigen in the presence of preexisting antibodies that are not directed against that new antigen, but that are directed against a kind of similar antigen, namely for example, the Wuhan spike protein in the vaccine. In another situation, and it's very similar, the immune system is confronted with an antigen that has two different forms.
So it is in fact confronted with an antigen in the presence of antibodies that are directed against a different form of the same spike antigen. I don't know whether this has been proven, but it's very likely that this could be the case when the spike protein is produced by mRNA vaccines if the first spike protein comes in a different conformation, for example in a monomeric form; in that case, antibodies will be built against this monomeric form and then those antibodies will recognize the full-fledged spike protein in the circulation which however is trimeric. So you see it's the same antigen but a different form.
Antibodies have been formed against a monomeric spike and then those antibodies are confronted with the same antigen as a spike protein which has a different conformational state, namely the trimeric form. Especially for coronaviruses there have been lots of publications about, the transport and the presentation in virus-infected cells of the monomeric spike protein versus the trimeric. But apparently when it comes to mRNA vaccines and production of the spike protein in our own body cells, this doesn't seem to be important (to investigate). But it is likely that this happens especially with mRNA vaccines that first of all antibodies get elicited against the monomeric spike protein and those are of course not the antibodies that optimally recognize the circulating spike protein in the blood. So, what happens with immune refocusing?
Well, in regard of immune refocusing, I’m just going to present the example of a breakthrough infection, that was the first case I was talking about. Well, obviously the pre-existing antibodies from the vaccine do not recognize very well the new antigen. This is the variant, the antigen of the variant that caused a breakthrough infection. So, these antibodies cannot neutralize the virus, this is the spike protein with different epitopes, but it can of course bind to that epitope.
And by binding to this epitope, this preexisting vaccinal antibodies can hide this epitope. What happens when it hides this epitope is that other epitopes will benefit from that. In a sense, these other epitopes were previously outcompeted by these stronger neutralizing epitopes that have now been masked by the preexisting antibodies. So that is why we call these epitopes ‘subdominant’. They are most likely less exposed to the immune system than the stronger neutralizing antibodies.
So by hiding the stronger neutralizing epitopes, the subdominant epitopes now gain, immunologically speaking, a competitive advantage. However, these less exposed domains of spike are less potent inducers of neutralizing antibodies. Now, in case somebody has been vaccinated and that is what we are talking about in case of breakthrough infections, , these subdominant epitopes now gain a competitive advantage and will be able to recall previously primed B memory cells that are producing antibodies which have a lower neutralizing capacity. So the subdominant epitopes that gain a competitive advantage because the strongest neutralizing epitopes have now been hidden by the existing preexisting vaccinational antibodies, are now going to be able to recall in a pre-primed, i.e., a vaccine-primed individual, previously primed antibodies or memory cells that are producing antibodies that have less neutralizing capacity.
That is what I'm calling here the ‘hidden antigenic sin’. Why hidden? Because they are not promoting the stimulation, so to say, of the original vaccinal antibodies, despite reinfection. No, they are eliciting antibodies that were not previously elicited or that were only elicited in very, very low quantities because the antigens that were inducing them were dominated and outcompeted by the stronger neutralizing epitopes. So now we get to a situation where these subdominant epitopes are recalling antibodies with less neutralizing capacity.
Of course, because these antibodies have now lower neutralizing capacity, they can put this epitope under huge immune pressure. And because of that huge immune pressure that these antibodies with low neutralizing capacity exert on this subdominant epitopes immune escape will be promoted. It will promote natural selection of mutations of this epitope that are capable of escaping those antibodies. And of course, when these new mutants or new variants are now going to reinfect people, one will have a kind of similar situation as the one that I described above, where this preexisting antibodies (see arrow: these are now the preexisting antibodies) do not recognize very well this mutated epitope and they will hide it. And by hiding it, they will now favor the immunogenicity of other epitopes that have even lower potency to induce neutralizing antibodies.
And because these epitopes that have now lower potential capacity to induce neutralizing antibodies, they are of course going to be able to recall memory B cells that secrete antibodies that have even lower neutralizing capacity. Again, hidden antigenic sin. And because this lower neutralization capacity will exert huge pressure immune pressure on this epitope, this epitope will now easily evade these antibodies and mutations will be selected that can overcome the immune pressure exerted by these antibodies. And it continues, of course, like this. Because, again, now the situation is that these preexisting antibodies will not well recognize yet another antigen with even lower neutralizing capacity.
And this will lead in fact to a situation where breakthrough infections are causing an increased proportion of poorly neutralizing to even non neutralizing antibodies. And that is the system that will expedite and accelerate immune escape as never seen before. So, what is the conclusion of this? Well, in fact, the conclusion, if you think about this, is that the emerging omicron variants, by virtue of causing breakthrough infections, are putting themselves under growing immune pressure because they are recalling vaccine-induced antibodies with decreasing neutralizing capacity.
So, the Omicron variants themselves are eliciting immune responses by virtue of recalling vaccine-induced antibodies with decreasing neutralizing incapacity. The Omicron variants are themselves eliciting immune responses that will put immune pressure on the very variant that has caused the recall of these immune responses with low neutralizing capacity. So, you can already imagine that when these Omicron variants circulate and you get these breakthrough infections over and over again, that this will lead to a vicious circle which is going to escalate the rate of immune escape. It already explains, of course, why also updated vaccines, so to say adapted to Omicron, are a complete nonsense. This is an insult to the science. How can you be so stupid? It can only be if you have no clue about this mechanism of immune refocusing. And there are now many, many publications that describe the evolution of how the immune response is getting enriched in poorly neutralizing and non-neutralizing antibodies.
And all of these data are completely compatible with this theory of immune refocusing and hidden antigenic sin. So, because of that, we are seeing now converging receptor-binding domain mutations, so, mutations in the receptor binding domain that are now even enhancing the infectiousness of the virus. So, you first have poorly neutralizing antibodies that are promoted, so to say, or that are recalled, then they are less and less neutralizing, even non-neutralizing. And at the end, what is going on right now as we speak, is that we see in all these variants converging mutations in the receptor-binding domain that are now even enabling enhanced infectiousness of the virus.
These are typically the mutations that we now see that provided strains like the gamma and delta variant with enhanced infectiousness. So, as I was saying, it is a complete nonsense. And even the idea of the updated Omicron vaccines is just going to make things much, much worse for the reasons that I was sharing with you: the immune refocusing. So I cannot believe this, that there are professors, leaders of institutes for molecular biology, genetics, et cetera, et cetera who come up with the type of statements shown in this slide. And when I see their argumentation or their reasoning, what could possibly be the pluses and the minuses, the pros and cons of these Omicron-adapted vaccines, these updated vaccines, I mean, this is a shame.
None of this has anything to do with the science. This is not a scientific rational. There is no immunology in this. I mean, this is just, you know, the type of things they shared on Twitter, on all kinds of platforms and it is a complete nonsense. How can somebody, even being a professor, not understand the immune biology of the virus and start to make these kind of statements while making people believe that they are the experts and that what they are saying is something that is completely compatible in fact, with what is published in the literature. It is not!
I mean, this is completely worthless.
So what will be the consequences now of this enhanced immune escape in vaccines, how will these consequences of this enhanced immune escape evolve? And I would say to the fact checkers, please wait. If you want to vilify me or ridicule me, that's fine. But just wait for the next few weeks or months to see what is happening because I am going to predict what is happening.
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https://www.voiceforscienceandsolidarity.org/videos-and-interviews/it-is-5-past-12